Nitrogen mustard compounds
Medchemexpress LLC Metarrestin | 1443414-10-5 | 99.9% | 25MG
Metarrestin | 1443414-10-5 | 99.9% | 25MG
Medchemexpress LLC Mizagliflozin | 666843-10-3 | 99.2% | 564.67 | 100 MG
Mizagliflozin, also known by its synonyms DSP-3235 free base, KGA-3235 free base, and GSK-1614235 free base, is a highly potent and orally active compound primarily recognized as a selective inhibitor of SGLT1 (sodium-glucose cotransporter 1). Its inhibitory constant (Kᵢ) against human SGLT1 is 27 nM, showcasing a remarkable selectivity profile with 303-fold greater potency for SGLT1 compared to SGLT2. This selectivity makes it a promising antidiabetic agent, as it can effectively modify postprandial blood glucose excursion, helping to manage blood sugar levels after meals. Beyond its antidiabetic properties, Mizagliflozin has also demonstrated potential in alleviating chronic constipation, exhibiting a laxative effect in animal models.
- Potent and selective SGLT1 inhibitor
- Orally active compound
- Modifies postprandial blood glucose excursion
- Potential in ameliorating chronic constipation
Selleck Chemical LLC Camonsertib-E1108-5MG
Camonsertib is a highly potent and selective inhibitor of ATR kinase with an IC50 of 1 nM
Medchemexpress LLC KB-5492 (anhydrous) | 129200-10-8 | 99.5% | 546.57 | 5 MG
KB-5492 anhydrous is a potent and selective inhibitor of the sigma receptor, inhibiting specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding with an IC50 of 3.15 μM. It also functions as an anti-ulcer agent, preventing ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells in vitro, and macroscopic lesions in the gastric mucosa in vivo.
- Potent and selective sigma receptor inhibitor
- Inhibits specific DTG binding in a concentration-dependent manner
- Prevents ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells
- Prevents macroscopic lesions in the gastric mucosa in animal models
- Suitable for research use only
eMolecules 223671-10-1 | ChemScene | 47-Dibromoisoquinoline | 100mg | 642098069 | CS-0139734 | MFCD13191776 | 286.954 | C9H5Br2N
Ambeed | 3-(Bromomethyl)benzamide | 250mg | 552580949 | A143879 | 509073-67-0 | MFCD23135264 | 214.062 | C8H8BrNO
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![Medchemexpress LLC 5-amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide | 1451994-10-7 | 99.3% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234551.png-250.jpg)
Medchemexpress LLC 5-amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide | 1451994-10-7 | 99.3% | 100 MG
VU0467485 (AZ13713945) is a potent, selective, orally bioavailable positive allosteric modulator of the muscarinic acetylcholine receptor M4. It is supplied for research use and exhibits CNS penetration and antipsychotic-like activity in preclinical models.
- Potent M4 positive allosteric modulator
- Selective over M1, M2, M3, and M5 receptors
- Orally bioavailable with CNS penetration
- High purity suitable for research applications
- Provided as a 100 mg pack for assay and preclinical studies
Medchemexpress LLC 2-chloroethyl (2-chloroethyl)phosphonate | 17378-30-2 | MFCD24393365 | 98.0% | 206.99 g/mol | C4H9Cl2O3P | 100 MG
2-Chloroethyl (2-chloroethyl)phosphonate is an organophosphorus compound used primarily as an intermediate in organic synthesis and building-block chemistry. It has molecular formula C4H9Cl2O3P and a molecular weight of 206.99 g/mol. Typical applications include incorporation into multi-step syntheses; quality attributes such as purity and recommended storage should be confirmed from the certificate of analysis.
Medchemexpress LLC Senkyunolide A | 63038-10-8 | 192.26 | 5 MG
Senkyunolide A is a phthalide with anticancer activity, acting as an anti-tumor cell proliferation agent. It offers neuroprotective effects by decreasing protein phosphatase PP2A and α-synuclein phosphorylation, and inhibits osteoarthritis by modulating the NLRP3 signaling pathway. Furthermore, it suppresses the expression of CD137, a biomarker for atherosclerosis.
- Inhibits proliferation of HT-29 and CCD-18Co cells.
- Decreases high expression of CD137 in TNF-α treated MAECs cells.
- Enhances cell viability and reduces apoptosis in PC12 cells.
- Stimulates cell proliferation and curbs apoptosis in IL-1β-treated chondrocytes.
- Inhibits cell inflammation by blocking the NLRP3 signaling pathway.
- Demonstrates improvement in mouse models of osteoarthritis, alleviating articular cartilage destruction.
Medchemexpress LLC 2'-O-Methylisoliquiritigenin | 51828-10-5 | 270.28 | 5 MG
2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA, and GABA pathways, though its effect on the NE pathway is not significant. This compound has shown sedative-hypnotic and anxiolytic effects in mice studies and acts on 5-HT, Dopamine, and GABA Receptors, engaging GPCR/G Protein and Neuronal Signaling pathways. It is intended for research use only.
- Isolated from Arachis species.
- Up-regulates 5-HT, NE, DA, and GABA pathways.
- Acts on 5-HT Receptor, Dopamine Receptor, and GABA Receptor.
- Engages GPCR/G Protein and Neuronal Signaling pathways.
- Has sedative-hypnotic and anxiolytic effects.
- Appears as a solid with a light yellow to yellow color.
Medchemexpress LLC 2-chloroethyl (2-chloroethyl)phosphonate | 17378-30-2 | MFCD24393365 | 98.0% | 206.99 | C4H9Cl2O3P | 25 MG
2-Chloroethyl (2-chloroethyl)phosphonate is an organophosphorus compound used as an intermediate in organic synthesis. It has molecular formula C4H9Cl2O3P and a molecular weight of 206.99 g/mol. Store the material under the conditions recommended in the certificate of analysis and consult the product data sheet for technical details.
- Organophosphorus compound used as an intermediate in organic synthesis.
- Molecular formula C4H9Cl2O3P and molecular weight 206.99 g/mol.
- Contains chloroethyl and phosphonate functional groups.
- Suitable for small-scale research and synthetic applications.
- Store under recommended conditions per certificate of analysis.
- Product data sheet available for technical reference.
Medchemexpress LLC β-catenin-IN-2 | 1458664-10-2 | 99.6% | C15H14FN3 | 10MG
β-catenin-IN-2 (Compound H1B1) is a small-molecule inhibitor of β-catenin intended for preclinical research, particularly studies of colorectal cancer and Wnt/β-catenin signaling. The compound is characterized by CAS 1458664-10-2, molecular formula C15H14FN3, molecular weight 255.29, and is supplied with analytical documentation for research use.
- Potent β-catenin inhibitor suitable for cellular and biochemical assays.
- Reported applicability in colorectal cancer research.
- High purity (99.6%) for reliable experimental results.
- Characterized with COA, HNMR, and LCMS data available.
- Small-molecule properties: molecular weight 255.29, formula C15H14FN3.
eMolecules 2252415-10-2 | Ambeed | Borate(1-) trifluoro(2-fluoro-6-hydroxyphenyl)- potassium (11) | 1g | 660580557 | A1147041 | 218 | C6H4BF4KO
Ambeed | 4-Methoxypyridine-26-dicarboxylic acid | 250mg | 525070681 | A156829 | 52062-26-7 | MFCD11036211 | 197.146 | C8H7NO5
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Medchemexpress LLC R-sulforaphane | 142825-10-3 | >98.0% | C6H11NOS2 | 10MG
(R)-Sulforaphane is the R-enantiomer of sulforaphane, an organosulfur isothiocyanate (CAS 142825-10-3) that induces phase II detoxification enzymes and activates the Nrf2 antioxidant pathway. It is used in biochemical and cell-based research to study antioxidant response, detoxification, inflammation, and cancer-related signaling. Supplied as a purified research-grade compound (purity >98%).
- Chiral R-enantiomer with defined stereochemistry.
- Activates Nrf2-mediated antioxidant response.
- Induces phase II detoxification enzymes.
- Suitable for cell-based and biochemical assays.
- High purity for reproducible results.
- Small, well-characterized organic molecule (C6H11NOS2, 177.29 g/mol).
Medchemexpress LLC Methyl (4-((4-fluorobenzyl)(prop-2-yn-1-yl)amino)-2,6-dimethylphenyl)carbamate | 1821222-10-9 | MFCD34676457 | 99.5% | C20H21FN2O2 | 10MG
HN37 is a small-molecule KCNQ2 (Kv7) activator intended for laboratory research use. It exhibits potent neuronal Kv7 activation with reported antiepileptic activity (EC50 ≈ 37 nM) and contains an alkyne functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and probe synthesis. The compound is provided as a high-purity solid or DMSO solution for experimental use.
- Potent KCNQ2 (Kv7) activator with EC50 ≈ 37 nM.
- Contains an alkyne group for CuAAC click chemistry.
- High purity (99.53%) suitable for research applications.
- Supplied in solid and DMSO solution formats.
- Intended for laboratory research only; not for human use.
Medchemexpress LLC Alamandine | 1176306-10-7 | 99.9% | 855.00 | 5 MG
Alamandine | 1176306-10-7 | 99.9% | 855.00 | 5 MG